Claudina A. Pérez Novo
(IPMB 2000)
Positions held since graduation:
2000-2001: Pre- doctoral training in the Department of Othorhinolaryngology, Ghent University Hospital, Belgium.
2001-2003: Doctoral training in the Department of Othorhinolaryngology. Grant from the Faculty of Medicine, Ghent University Hospital, Belgium.
2003-2006: Doctoral in the Department of Othorhinolaryngology, Ghent University Hospital, Belgium (BOF Grant from the University of Ghent).
2008- 2012: Post- Doc researcher at the Department of Othorhinolaryngology, Ghent University, Belgium (FWO mandate)
Major tasks:
Post-doc researcher
List of publications:
Pérez C, Vandesompele J, Vandenbroucke I, Holtappels G, Speleman F, Gevaert P, Van Cauwenberge P, Bachert C. Quantitative Real Time Polymerase Chain Reaction for measurement of human Interleukin - 5 receptor alpha spliced isoforms mRNA. BMC Biotechnology 2003; 3:17- 26.
Gevaert P, Bachert C, Holtappels G, Novo CP, Van der Heyden J, Fransen L, Depraetere S, Walter H, van Cauwenberge P, Tavernier J. Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis. Allergy 2003; 58: 371- 379.
Watelet JB, Claeys C, Pérez-Novo C, Gevaert P, Van Cauwenberge P, Bachert C. Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis. American Journal of Rhinology 2004; 18: 267- 72.
Pérez-Novo CA, Kowalski ML, Kuna P, Ptasinska A, Holtappels G, van Cauwenberge P, Gevaert P, Johannson S, Bachert C. Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: studies on the relationship. International Archives of Allergy and Immunology 2004; 133: 255- 60.
Pérez- Novo CA, Claeys C, Speleman F, Van Cauwenberge P, Bachert C, Vandesompele J. Impact of RNA quality on reference gene expression stability. Biotechniques 2005; 39: 52- 56.
Pérez- Novo CA, Watelet JB, Claeys C, Van Cauwenberge P, Bachert C. Prostaglandin, Leukotriene and Lipoxin balance in Chronic Rhinosinusitis with and without Nasal Polyposis. Journal of Allergy and Clinical Immunology 2005; 115: 1189- 1196.
Zhang N, Gevaert P, Van Zele T, Pérez- Novo C, Patou J, Holtappels G, Van Cauwenberge P, Bachert C. An update on the impact of staphylococcus aureus enterotoxins in chronic rhinosinusitis with nasal polyposis. Rhinology 2005; 43: 162- 168.
Pérez- Novo CA, Claeys C, Van Zele T, Van Cauwenberge P, Bachert C. Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. American Journal of Rhinology 2005; 4: 456-60.
Pérez-Novo CA, Claeys C, Van Cauwenberge P, Bachert C. Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis. Respiratory Research. 2006; 7: 75-80.
Bachert C, Gevaert P, Zhang N, van Zele T, Pérez-Novo C. Staphylococcal superantigens in airway disease: A review. Part 1: The role of S-aureus enterotoxins in allergic rhinitis and nasal polyps. Allergologie 2007; 30: 129-138.
Bachert C, Zhang N, Gevaert P, Van Zele T, Pérez-Novo C. Role of staphylococcal superantigens in airway disease: A review. Part 2: S-aureus enterotoxins in AERD, asthma, early childhood wheezing and COPD. Allergologie 2007; 30: 155-164.
Pérez-Novo CA, Waeytens A, Claeys C, Van Cauwenberge P, Bachert C. Staphylococcus aureus Enterotoxin B Regulates Prostaglandin E2 Synthesis, Growth and Migration in Nasal Tissue Fibroblasts. Journal of Infectious Diseases 2008; 197: 1036-1043.
Ferdinande L, Demetter P, Pérez-Novo C, Waeytens A, Taildeman J, Rottiers I, Rottiers P, De Vos M, Cuvelier CA. Inflamed intestinal mucosa features a specific epithelial expression pattern of indoleamine 2,3-dioxygenase. Int J Immunopathol Pharmacol. 2008; 21:289-95.
Van Bruaene N, Pérez-Novo CA, Basinski TM, Van Zele T, Holtappels G, De Ruyck N, Schmidt-Weber C, Akdis C, Van Cauwenberge P, Bachert C, Gevaert P. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol. 2008; 121:1435-41.
Zhang N, Van Zele T, Pérez-Novo C, Van Bruaene N, Holtappels G, Deruyck N, Van Cauwenberge P, Bachert C. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease.J Allergy Clin Immunol. 2008; 122:961-8
Van Bruaene N, Derycke L, Pérez-Novo CA, Gevaert P, Holtappels G, De Ruyck N, Cuvelier C, Van Cauwenberge P, Bachert C. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol. 2009; 124 : 253-9.
Patou J, Holtappels G, Affleck K, Gevaert P, Pérez-Novo C, Van Cauwenberge P, Bachert C. Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue. J Inflamm (Lond). 2009; 6:11.
Pérez-Novo CA, Holtappels G, Vinall SL, Xue L, Zhang N, Bachert C, Pettipher R. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. Allergy. 2009 Oct 12.
Taildeman J, Demetter P, Rottiers I, Holtappels G, Bachert C, Cuvelier CA, Pérez-Novo CA. Identification of the nasal mucosa as a new target for leptin action. Journal of Histopathology, in press.
Book’s chapters
Bachert C, Gevaert P, Zhang N, Van Zele T, Pérez-Novo C: Role of Staphylococcal Superantigens in Airway Disease. Chem Immunol Allergy. 2007;93:214-36. In: G. Marone (ed): Superantigens and Superallergens, Karger, Basel 2007.
Peter T, Van Zele T, Gevaert P, Zhang N, Pérez-Novo C, Van Bruaene N, Patou J, Bachert C. Staphylococcus aureus-derived superantigens in nasal polyp disease. In Nasal polyposis 2010, (Ed): Önerci Metin and Ferguson Berrylin, Springer, Heidelberg.
Projects involved in:
Role of eicosanoids in T-cell and dendritic cell activation in chronic rhinosinusitis/nasal polyp and aspirin exacerbated respiratory disease
Epigenetics events regulating the inflammatory process of chronic airway diseases
(IPMB 2000)
Positions held since graduation:
2000-2001: Pre- doctoral training in the Department of Othorhinolaryngology, Ghent University Hospital, Belgium.
2001-2003: Doctoral training in the Department of Othorhinolaryngology. Grant from the Faculty of Medicine, Ghent University Hospital, Belgium.
2003-2006: Doctoral in the Department of Othorhinolaryngology, Ghent University Hospital, Belgium (BOF Grant from the University of Ghent).
2008- 2012: Post- Doc researcher at the Department of Othorhinolaryngology, Ghent University, Belgium (FWO mandate)
Major tasks:
Post-doc researcher
List of publications:
Pérez C, Vandesompele J, Vandenbroucke I, Holtappels G, Speleman F, Gevaert P, Van Cauwenberge P, Bachert C. Quantitative Real Time Polymerase Chain Reaction for measurement of human Interleukin - 5 receptor alpha spliced isoforms mRNA. BMC Biotechnology 2003; 3:17- 26.
Gevaert P, Bachert C, Holtappels G, Novo CP, Van der Heyden J, Fransen L, Depraetere S, Walter H, van Cauwenberge P, Tavernier J. Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis. Allergy 2003; 58: 371- 379.
Watelet JB, Claeys C, Pérez-Novo C, Gevaert P, Van Cauwenberge P, Bachert C. Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis. American Journal of Rhinology 2004; 18: 267- 72.
Pérez-Novo CA, Kowalski ML, Kuna P, Ptasinska A, Holtappels G, van Cauwenberge P, Gevaert P, Johannson S, Bachert C. Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: studies on the relationship. International Archives of Allergy and Immunology 2004; 133: 255- 60.
Pérez- Novo CA, Claeys C, Speleman F, Van Cauwenberge P, Bachert C, Vandesompele J. Impact of RNA quality on reference gene expression stability. Biotechniques 2005; 39: 52- 56.
Pérez- Novo CA, Watelet JB, Claeys C, Van Cauwenberge P, Bachert C. Prostaglandin, Leukotriene and Lipoxin balance in Chronic Rhinosinusitis with and without Nasal Polyposis. Journal of Allergy and Clinical Immunology 2005; 115: 1189- 1196.
Zhang N, Gevaert P, Van Zele T, Pérez- Novo C, Patou J, Holtappels G, Van Cauwenberge P, Bachert C. An update on the impact of staphylococcus aureus enterotoxins in chronic rhinosinusitis with nasal polyposis. Rhinology 2005; 43: 162- 168.
Pérez- Novo CA, Claeys C, Van Zele T, Van Cauwenberge P, Bachert C. Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. American Journal of Rhinology 2005; 4: 456-60.
Pérez-Novo CA, Claeys C, Van Cauwenberge P, Bachert C. Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis. Respiratory Research. 2006; 7: 75-80.
Bachert C, Gevaert P, Zhang N, van Zele T, Pérez-Novo C. Staphylococcal superantigens in airway disease: A review. Part 1: The role of S-aureus enterotoxins in allergic rhinitis and nasal polyps. Allergologie 2007; 30: 129-138.
Bachert C, Zhang N, Gevaert P, Van Zele T, Pérez-Novo C. Role of staphylococcal superantigens in airway disease: A review. Part 2: S-aureus enterotoxins in AERD, asthma, early childhood wheezing and COPD. Allergologie 2007; 30: 155-164.
Pérez-Novo CA, Waeytens A, Claeys C, Van Cauwenberge P, Bachert C. Staphylococcus aureus Enterotoxin B Regulates Prostaglandin E2 Synthesis, Growth and Migration in Nasal Tissue Fibroblasts. Journal of Infectious Diseases 2008; 197: 1036-1043.
Ferdinande L, Demetter P, Pérez-Novo C, Waeytens A, Taildeman J, Rottiers I, Rottiers P, De Vos M, Cuvelier CA. Inflamed intestinal mucosa features a specific epithelial expression pattern of indoleamine 2,3-dioxygenase. Int J Immunopathol Pharmacol. 2008; 21:289-95.
Van Bruaene N, Pérez-Novo CA, Basinski TM, Van Zele T, Holtappels G, De Ruyck N, Schmidt-Weber C, Akdis C, Van Cauwenberge P, Bachert C, Gevaert P. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol. 2008; 121:1435-41.
Zhang N, Van Zele T, Pérez-Novo C, Van Bruaene N, Holtappels G, Deruyck N, Van Cauwenberge P, Bachert C. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease.J Allergy Clin Immunol. 2008; 122:961-8
Van Bruaene N, Derycke L, Pérez-Novo CA, Gevaert P, Holtappels G, De Ruyck N, Cuvelier C, Van Cauwenberge P, Bachert C. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol. 2009; 124 : 253-9.
Patou J, Holtappels G, Affleck K, Gevaert P, Pérez-Novo C, Van Cauwenberge P, Bachert C. Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue. J Inflamm (Lond). 2009; 6:11.
Pérez-Novo CA, Holtappels G, Vinall SL, Xue L, Zhang N, Bachert C, Pettipher R. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. Allergy. 2009 Oct 12.
Taildeman J, Demetter P, Rottiers I, Holtappels G, Bachert C, Cuvelier CA, Pérez-Novo CA. Identification of the nasal mucosa as a new target for leptin action. Journal of Histopathology, in press.
Book’s chapters
Bachert C, Gevaert P, Zhang N, Van Zele T, Pérez-Novo C: Role of Staphylococcal Superantigens in Airway Disease. Chem Immunol Allergy. 2007;93:214-36. In: G. Marone (ed): Superantigens and Superallergens, Karger, Basel 2007.
Peter T, Van Zele T, Gevaert P, Zhang N, Pérez-Novo C, Van Bruaene N, Patou J, Bachert C. Staphylococcus aureus-derived superantigens in nasal polyp disease. In Nasal polyposis 2010, (Ed): Önerci Metin and Ferguson Berrylin, Springer, Heidelberg.
Projects involved in:
Role of eicosanoids in T-cell and dendritic cell activation in chronic rhinosinusitis/nasal polyp and aspirin exacerbated respiratory disease
Epigenetics events regulating the inflammatory process of chronic airway diseases